Research in the Smith lab focuses on the acute inflammation and endothelial response to acute surgical stress.  Clinical outcomes of interest include postoperative acute kidney injury and delirium.  Study techniques include clinical studies of surgical patients, in vivo mechanistic studies (mice), and in vitro human primary cell experiments. Current studies focus on single-cell spatial transcriptomic characterization of the human endothelial response to surgery including cell-cell interaction prediction modeling as well as characterization of the surgically triggered “genomic storm” in human PBMCs and endothelial cells.  The laboratory also has ongoing projects examining the protective role of high-density lipoproteins in these biological pathways and processes, with the goal of developing novel lipoprotein-based therapies for perioperative protection.  We are looking for an enthusiastic and diligent post-baccalaureate research intern who is interested in joining our team and gaining laboratory and research experience and who has a deep desire to improve the outcomes of surgical patients through research.

BA or BS degree (or equivalent) in a field related to molecular medicine

The applicant is expected to have excellent interpersonal skills, English writing skills, organizational skills, and a strong attention to detail.